Diisopropyl Ether → HCID 22118557, compound

HRID 1274966Notes

Reaction equation

HRID 1274966 reaction equation
[C:1](OC(=O)C)(=[O:3])C.[NH2:8][C:9]1[S:10][C:11]([F:20])=[C:12](/[C:14](=[N:18]/[OH:19])/[C:15]([OH:17])=[O:16])[N:13]=1.[CH:21]([O:24]C(C)C)(C)C>C(O)=O>[F:20][C:11]1[S:10][C:9]([NH:8][CH:1]=[O:3])=[N:13][C:12]=1/[C:14](=[N:18]/[O:19][CH:21]=[O:24])/[C:15]([OH:17])=[O:16]

Participants

5

Reactant 3

HCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 22118572HCID 22118572, compound

Product 1

HCID 22118557HCID 22118557, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Conditions

Temperature
30 °C

Procedure

A mixture of acetic anhydride (2.7 ml) and formic acid (2.2 ml) was stirring for 30 minutes at 30° C. 2-(2-Amino-5-fluorothiazol-4-yl)-2-(Z)-(hydroxyimino)acetic acid (1.2 g) was added thereto with stirring under ice cooling, and the mixture was stirred for 3 hours at 25 to 35° C. The reaction mixture was poured into an isopropyl ether (50 ml). The resulting precipitate was collected by filtration, dried under reduced pressure to give 2-(5-fluoro-2-formylaminothiazol-4-yl) -2-(Z)-(formyloxyimino) acetic acid (0.65 g).

Workup

  1. stirringwith stirring under ice cooling
  2. stirringthe mixture was stirred for 3 hours at 25 to 35° C
  3. filtrationThe resulting precipitate was collected by filtration
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-1b8fdad2822a4ae5bcf09362415501d4
Source dataset
uspto-grants-2000_12
Patent number
US06159961

Reaction notes

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