HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloride 2-chloropyridinium 1-oxide → HCID 178453505, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloride 2-chloropyridinium 1-oxide | HCID 88478 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | tert-Butyl (3-aminopropyl)carbamate | HCID 2735700 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | 2-Methyl-2-butanol | HCID 6405 | — |
| Product | HCID 178453505 | HCID 178453505 | — |
Reaction Steps
A mixture of N-Boc-1,3-diaminopropane (3.48 g, 20 mmol), 2-chloropyridine N-oxide hydrochloride (3.98 g, 24 mmol), and NaHCO3 (8.40 g, 100 mmol) in tert-amyl alcohol (50 mL) is heated at reflux under argon. After 48 h, the reaction is cooled, diluted with EtOH, filtered, and concentrated. The residue is reconcentrated from toluene and chromatographed (silica gel) to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06159964 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-05df74a38b1a43cf85b023cc486ce033 |
| Source note | uspto-grants-2000_12 |