HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(6-Nitroindolin-1-yl)ethanone → 1-Acetyl-6-aminoindoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(6-Nitroindolin-1-yl)ethanone | HCID 258566 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Acetyl-6-aminoindoline | HCID 258564 | 95% |
Reaction Steps
A stirred suspension of 1-acetyl-2,3-dihydro-6-nitro-1H-indole (D9, 125 g, 0.61 mole) in THF (5500 ml) was hydrogenated over 10% Pd-C (20 g) at 50 psi for 20 h. The catalyst was removed by filtration through a plug of kieselguhr and the filtrate concentrated in vacuo to afford the title compound as a beige solid (102 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06159979 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-cf38a93b1ec34dc4aa53d5c96bcf3c32 |
| Source note | uspto-grants-2000_12 |