反应详情

A stirred suspension of 1-acetyl-2,3-dihydro-6-nitro-1H-indole (D9, 125 g, 0.61 mole) in THF (5500 ml) was hydrogenated over 10% Pd-C (20 g) at 50 psi for 20 h. The catalyst was removed by filtration through a plug of kieselguhr and the filtrate concentrated in vacuo to afford the title compound as a beige solid (102 g, 95%).

1. customThe catalyst was removed by filtration through a plug of kieselguhr
2. concentrationthe filtrate concentrated in vacuo