4-Bromo-3-(4-methylpiperazin-1-yl)aniline → N-[4-Bromo-3-(4-methylpiperazin-1-yl)phenyl]-4-(pyridin-4-yl)naphth-1-ylacetamide

HRID 1275029Notes

Reaction equation

HRID 1275029 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[C:10]([CH2:17][C:18](O)=[O:19])=[CH:9][CH:8]=2)=[CH:3][CH:2]=1.[Br:21][C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[CH:24][C:23]=1[N:29]1[CH2:34][CH2:33][N:32]([CH3:35])[CH2:31][CH2:30]1>>[Br:21][C:22]1[CH:28]=[CH:27][C:25]([NH:26][C:18](=[O:19])[CH2:17][C:10]2[C:11]3[C:16](=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:7]([C:4]3[CH:3]=[CH:2][N:1]=[CH:6][CH:5]=3)=[CH:8][CH:9]=2)=[CH:24][C:23]=1[N:29]1[CH2:30][CH2:31][N:32]([CH3:35])[CH2:33][CH2:34]1

Participants

3

Reactant 2

HCID 181800994-Bromo-3-(4-methylpiperazin-1-yl)aniline2×HCID 224625334-(Pyridin-4-yl)naphth-1-ylacetic acid

Product 1

HCID 22118918N-[4-Bromo-3-(4-methylpiperazin-1-yl)phenyl]-4-(pyridin-4-yl)naphth-1-ylacetamide

Procedure

The title compound was prepared from 4-(pyridin-4-yl)naphth-1-ylacetic acid (D2) and 4-bromo-3-(4-methylpiperazin-1-yl)aniline (Intermediate 44, EP 0533268A1) using a similar procedure to Example 20 (73%).

Sources & evidence

ORD record
ord-bb94bff4b15249f8af1f2bac33adfca9
Source dataset
uspto-grants-2000_12
Patent number
US06159979

Reaction notes

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