참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Stannous chloride dihydrate | HCID 61436 | — |
| 반응물 | 7-Bromo-5-nitrobenzothiazole | HCID 22728031 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | 7-Bromobenzo[d]thiazol-5-amine | HCID 22728037 | 9,687.5% |
반응 단계
To a solution of SnCl2.2H2O (0.5 g, 2.2 mmol) in 5 mL of HCl was added 5-nitro-7-bromobenzothiazole (82 mg, 0.32 mmol) in a portion and the resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aq. NaOH and extracted with EtOAc. Organic extracts were dried over Na2SO4 and concentrated in vacuo to yield 70 mg (31 mmol, 96%) of the desired product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06159998 |
|---|
| 출처 데이터셋 | uspto-grants-2000_12 |
|---|
| ORD ID | ord-e3f72e5bbecd4bf8b7248ad540840bfb |
|---|
| 출처 메모 | uspto-grants-2000_12 |
|---|
