Sodium Hydroxide → 7-Bromobenzo[d]thiazol-5-amine

HRID 1275098노트

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HRID 1275098 반응식
O.O.Cl[Sn]Cl.[N+:6]([C:9]1[CH:10]=[C:11]([Br:18])[C:12]2[S:16][CH:15]=[N:14][C:13]=2[CH:17]=1)([O-])=O.[OH-].[Na+]>Cl>[NH2:6][C:9]1[CH:10]=[C:11]([Br:18])[C:12]2[S:16][CH:15]=[N:14][C:13]=2[CH:17]=1

참가 물질

5

반응물 3

HCID 14798Sodium HydroxideHCID 61436Stannous chloride dihydrateHCID 227280317-Bromo-5-nitrobenzothiazole

생성물 1

HCID 227280377-Bromobenzo[d]thiazol-5-amine수율 9,687.5%

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

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온도
25 °C

실험 절차

To a solution of SnCl2.2H2O (0.5 g, 2.2 mmol) in 5 mL of HCl was added 5-nitro-7-bromobenzothiazole (82 mg, 0.32 mmol) in a portion and the resulting reaction mixture was stirred for 1 h at 25° C. The reaction mixture was basified with aq. NaOH and extracted with EtOAc. Organic extracts were dried over Na2SO4 and concentrated in vacuo to yield 70 mg (31 mmol, 96%) of the desired product.

후처리

  1. customthe resulting reaction mixture
  2. extractionextracted with EtOAc
  3. dry with materialOrganic extracts were dried over Na2SO4
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e3f72e5bbecd4bf8b7248ad540840bfb
출처 데이터셋
uspto-grants-2000_12
특허 번호
US06159998

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