N,N'-Dimethylthiourea → HCID 20638585, compound

HRID 1275113Notes

Reaction equation

HRID 1275113 reaction equation
Br.[C:2]([C:6]1[CH:7]=[CH:8][C:9]2[CH2:10][CH:11]3[S:15][C:14](=[N:16][CH3:17])[N:13]([CH3:18])[C:12]3([OH:21])[C:19]=2[CH:20]=1)([CH3:5])([CH3:4])[CH3:3].[Br:22]C1CC2C(=CC(C(C)(C)C)=CC=2)C1=O.CNC(NC)=S>CC(C)=O>[BrH:22].[C:2]([C:6]1[CH:7]=[CH:8][C:9]2[CH2:10][CH:11]3[S:15][C:14](=[N:16][CH3:17])[N:13]([CH3:18])[C:12]3([OH:21])[C:19]=2[CH:20]=1)([CH3:5])([CH3:3])[CH3:4].[C:2]([C:6]1[CH:7]=[CH:8][C:9]2[CH2:10][CH:11]3[S:15][C:14](=[N:16][CH3:17])[N:13]([CH3:18])[C:12]3([OH:21])[C:19]=2[CH:20]=1)([CH3:5])([CH3:3])[CH3:4]

Participants

6

Reactant 3

HCID 2723631N,N'-DimethylthioureaHCID 20638585HCID 20638585, compoundHCID 221190322-Bromo-6-tert-butyl-2,3-dihydro-1H-inden-1-one

Product 2

HCID 20638585HCID 20638585, compoundHCID 20638586HCID 20638586, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5-tert-Butyl-3-methyl-2-methylimino-2,3,8,8a-tetrahydroindeno-[1,2-d]thiazol-3a-ol hydrobromide: The reaction of 267 mg of 2-bromo-6-tert-butylindan-1-one with 156 mg of N,N'-dimethylthiourea in 10 ml of acetone yields the hydrobromide of 5-tert-butyl-3-methyl-2-methylimino-2,3,8,8a-tetrahydroindeno[1,2-d]thiazol-3a-ol of melting point 277-279° C.

Sources & evidence

ORD record
ord-274588fa05694805a082778122effffa
Source dataset
uspto-grants-2000_12
Patent number
US06159996

Reaction notes

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