Hydrochloric Acid → 3H-Spiro[2-benzothiophene-1,4'-piperidine]--hydrogen chloride (1/1)

HRID 1275145Notes

Reaction equation

HRID 1275145 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][C:11]2([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[CH2:15][S:14]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:22]>C(Cl)Cl.O1CCOCC1>[ClH:22].[NH:8]1[CH2:13][CH2:12][C:11]2([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=3[CH2:15][S:14]2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 105665171'-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4'-piperidine]

Product 1

HCID 184274953H-Spiro[2-benzothiophene-1,4'-piperidine]--hydrogen chloride (1/1)Yield 91%

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

150 mg (0.49 mmole) of 1'-t-butoxycarbonylspiro[benzo[c]thiophene-1(3H),4'-piperidine] [prepared as described in step (b) above] were dissolved in 3 ml of anhydrous methylene chloride, and 1 ml of a 4 N solution of hydrogen chloride in dioxane was added. The mixture was then stirred at room temperature for 1 hour. At the end of this time, the crystals which deposited were collected by filtration, to give 108 mg (yield 91%) of the title compound as white crystals.

Workup

  1. filtrationAt the end of this time, the crystals which deposited were collected by filtration

Sources & evidence

ORD record
ord-c0051601ac6146e8af16513330e29ffe
Source dataset
uspto-grants-2000_12
Patent number
US06159967

Reaction notes

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