Ethanol → Ethyl 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethylhexanoate

HRID 127545Notes

Reaction equation

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10](=[O:19])[CH2:11][C:12]([CH3:18])([CH3:17])[CH2:13][C:14]([OH:16])=[O:15].S(=O)(=O)(O)O.[CH2:25](O)[CH3:26]>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[CH2:9][C:10](=[O:19])[CH2:11][C:12]([CH3:17])([CH3:18])[CH2:13][C:14]([O:16][CH2:25][CH3:26])=[O:15]

Participants

Reactant 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 136881246-(2',5'-Dimethylphenyl)-5-keto-3,3-dimethyl hexanoic acid

Product 1

HCID 13688125Ethyl 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethylhexanoateYield 78%

Procedure

Utilizing the procedure of EXAMPLE XX 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethyl hexanoic acid was esterified with absolute ethanol in the presence of a catalytic amount of concentrated sulfuric acid to provide 15.52 g (78% yield) of ethyl 6-(2',5'-dimethylphenyl)-5-keto-3,3-dimethylhexanoate as a pale viscous oil.

Sources & evidence

ORD record: ord-d30bd00a4f2d44b49a8bf4d70986adbe
Source dataset: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04256659

Reaction notes

Loading…