HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → 4-(2-Furylmethylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2-Chloromethyl-4-(2-furylmethylthio)-3-methylpyridine hydrochloride | HCID 22460771 | — |
| Reactant | pyridine-4-thiol | HCID 178418431 | — |
| Product | 4-(2-Furylmethylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine | HCID 22117354 | 89% |
Reaction Steps
According to the procedure indicated in Example 1, reaction of 4-mercaptopyridine with 2-chloromethyl-4-(2-furylmethylthio)-3-methylpyridine hydrochloride and sodium hydroxide solution, subsequent chromatography on silica gel (ethyl acetate/ethanol) and crystallization from diisopropyl ether gives the title compound as a colorless powder; m.p. 126-128° C.; yield 89% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162809 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-d061b64723b6416697c6dcd2e9bb1151 |
| Source note | uspto-grants-2000_12 |