反应详情

According to the procedure indicated in Example 7, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine with 1-benzylpiperazine and potassium carbonate in acetonitrile, after chromatography on silica gel and crystallization of the concentrated pure fraction from diisopropyl ether, gives the title compound as a colorless solid; m.p. 79-81° C.; yield 57% of theory. A hydrated hydrochloride can be prepared from isopropanol; m.p. 165° C. (dec.); yield 87% of theory.

1. customafter chromatography on silica gel and crystallization of the concentrated pure fraction from diisopropyl ether