Sodium Hydroxide → 3-Methyl-2-[(4-pyridinylthio)methyl]-4-[5-(4-pyridinyl)-1,5-dithiapentyl]pyridine

HRID 1275561Notes

Reaction equation

HRID 1275561 reaction equation
Cl[CH2:2][CH2:3][CH2:4][S:5][C:6]1[CH:11]=[CH:10][N:9]=[C:8]([CH2:12][S:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[C:7]=1[CH3:20].[SH:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1.[OH-].[Na+]>>[CH3:20][C:7]1[C:8]([CH2:12][S:13][C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)=[N:9][CH:10]=[CH:11][C:6]=1[S:5][CH2:4][CH2:3][CH2:2][S:21][C:22]1[CH:27]=[CH:26][N:25]=[CH:24][CH:23]=1

Participants

4

Reactant 3

HCID 14798Sodium HydroxideHCID 221173024-(3-Chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridineHCID 178418431pyridine-4-thiol

Product 1

HCID 221173343-Methyl-2-[(4-pyridinylthio)methyl]-4-[5-(4-pyridinyl)-1,5-dithiapentyl]pyridineYield 69%

Procedure

According to the procedure indicated in Example 5, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine with 4-mercaptopyridine and sodium hydroxide solution yields the title compound; m.p. 116-118° C.; Yield 69% of theory.

Sources & evidence

ORD record
ord-7097de1553204bc790ee244ffd364ff2
Source dataset
uspto-grants-2000_12
Patent number
US06162809

Reaction notes

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