HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 4-[3-(1-Imidazolyl)propylthio]-3-methyl-2-[(4-pyridinylthio)methyl]pyridin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(3-Chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine | HCID 22117302 | — |
| Product | 4-[3-(1-Imidazolyl)propylthio]-3-methyl-2-[(4-pyridinylthio)methyl]pyridin | HCID 22117315 | 32% |
Reaction Steps
According to the procedure indicated in Example 7, reaction of 4-(3-chloropropylthio)-3-methyl-2-[(4-pyridinylthio)methyl]pyridine with imidazole (2.0 equivalents) and potassium carbonate and subsequent chromatography on silica gel (dichloromethane/acetone/NH3 aq) gives, after crystallization from diisopropyl ether, the title compound; m.p. 117-119° C.; yield 32% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06162809 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-b1ae5573509b496e9096212d216b6b9a |
| Source note | uspto-grants-2000_12 |