HCID 18404138, compound → HCID 22117318, compound

HRID 1275569Notes

Reaction equation

HRID 1275569 reaction equation
[SH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=1.[ClH:8].[Cl:9][CH2:10][C:11]1[C:16]([CH3:17])=[C:15]([S:18][CH2:19][CH2:20][CH2:21][Cl:22])[CH:14]=[CH:13][N:12]=1>C(O)(C)C>[ClH:9].[ClH:8].[Cl:22][CH2:21][CH2:20][CH2:19][S:18][C:15]1[CH:14]=[CH:13][N:12]=[C:11]([CH2:10][S:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][N:3]=2)[C:16]=1[CH3:17]

Participants

4

Reactant 2

HCID 18404138HCID 18404138, compoundHCID 178418616HCID 178418616, compound

Product 1

HCID 22117318HCID 22117318, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

2-Mercaptopyridine (10 mmol) and 2-chloromethyl-4-(3-chloropropylthio)-3-methylpyridine hydrochloride (10 mmol) are heated to boiling in isopropanol (25 ml) for 4-6 h. After cooling, the precipitated solid is filtered off, washed with isopropanol and dried in vacuo at 40° C. 3.6 g (91% of theory) of the title compound are obtained as a colorless solid; m.p. 112-114° C. (dec.).

Workup

  1. temperatureAfter cooling
  2. filtrationthe precipitated solid is filtered off
  3. washwashed with isopropanol
  4. customdried in vacuo at 40° C

Sources & evidence

ORD record
ord-87376c2b6c0b4223be73e17bc85ca205
Source dataset
uspto-grants-2000_12
Patent number
US06162809

Reaction notes

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