反应详情

To a solution of 4-(benzyloxy)phenol (5.68 g, 28.4 mmol) in N,N-dimethylformamide (100 ml) was added potassium tert-butoxide (3.50 g, 31.2 mmol), and after stirring for 10 minutes, 1-chloro-4-ethoxy-2-nitrobenzene (5.73 g, 28.4 mmol) was added to the reaction solution, followed by stirring at 150° C. for 2 hours. The reaction solution was cooled to room temperature, poured into water and extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, and after drying, the solvent was evaporated under reduced pressure. The resulting crude crystals were recrystallized from methanol to give 4-[4-(benzyloxy)phenoxy]-3-nitrophenetole (7.18 g).

1. stirringby stirring at 150° C. for 2 hours
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. dry with materiala saturated aqueous sodium chloride solution, and after drying
5. customthe solvent was evaporated under reduced pressure
6. customThe resulting crude crystals were recrystallized from methanol