Pyridine → HCID 9825542, compound

HRID 1275710Notes

Reaction equation

HRID 1275710 reaction equation
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:9]=[CH:8][C:6]([NH2:7])=[CH:5][CH:4]=1.N1C=CC=CC=1.[CH2:18]([N:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:27]([C:34]2[O:35][C:36]([C:39](Cl)=[O:40])=[CH:37][CH:38]=2)=[N:26]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>C1COCC1>[CH2:18]([N:25]1[C:33]2[C:28](=[CH:29][CH:30]=[CH:31][CH:32]=2)[C:27]([C:34]2[O:35][C:36]([C:39](=[O:40])[NH:7][C:6]3[CH:8]=[CH:9][C:3]([C:2]([F:10])([F:11])[F:1])=[CH:4][CH:5]=3)=[CH:37][CH:38]=2)=[N:26]1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 1049PyridineHCID 99644-(Trifluoromethyl)anilineHCID 22480358HCID 22480358, compound

Product 1

HCID 9825542HCID 9825542, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.29 g (1.8 mmol) of 4-trifluoromethylaniline were initially charged in 20 ml of THF1 0.14 g (1.8 mmol) of pyridine were added and a solution of 0.5 g (1.5 mmol) of 1-benzyl-3-(5-chlorocarbonyl-2-furyl)indazole in 10 ml of THF was added dropwise at RT. After 0.5 h, the mixture was poured into ice-water and the precipitate was filtered off with suction and recrystallized from isopropanol. This gave 0.47 g (69%) of the title compound. m.p.: 205-206° C.

Workup

  1. additionwere added
  2. filtrationthe precipitate was filtered off with suction
  3. customrecrystallized from isopropanol

Sources & evidence

ORD record
ord-8d37a068c8c74e8489b9433534ca87ba
Source dataset
uspto-grants-2000_12
Patent number
US06162819

Reaction notes

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