反应详情

温度

40 °C

To a mixture of 0.17 g (0.5 mmol) Nα -(9-fluorenylmethoxycarbonyl)-L-serine methyl ester, 0.043 g (0.6 mmol) potassium carbonate and 0.083 g (0.5 mmol) potassium iodide in acetonitrile (2 mL) was added 0.16 g (0.5 mmol) of 9-bromo-9-phenyl-9H-fluorene (Aldrich), and the mixture stirred at 40° C. for 2 h. Filtration and removal of the solvent under vacuo gave the crude Nα -(9-fluorenylmethoxycarbonyl)-O-(9-phenyl-9H-fluoren-9-yl)-L-serine methyl ester which was subjected to the Fmoc deprotection in Step 2 without further purification.

1. filtrationFiltration and removal of the solvent under vacuo