Sulfuric Acid → HCID 54314549, compound

HRID 1275778Notes

Reaction equation

HRID 1275778 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:12]=[CH:11][S:10][C:9]=2[C:13]2([OH:26])[C:25]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:19]3[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=3)=[CH:4][CH:3]=1.C[O:28][C:29](=[O:52])[C@H:30]([C@@H:49]([CH3:51])O)[NH:31]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O.OS(O)(=O)=O>FC(F)(F)C(O)=O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:12]=[CH:11][S:10][C:9]=2[C:13]2([O:26][C@H:49]([CH3:51])[C@@H:30]([C:29]([OH:52])=[O:28])[NH2:31])[C:25]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[C:19]3[C:14]2=[CH:15][CH:16]=[CH:17][CH:18]=3)=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 11164107HCID 11164107, compoundHCID 22117507HCID 22117507, compound

Product 1

HCID 54314549HCID 54314549, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidCatalyst

Procedure

from 9-[3-(4-fluorophenyl)thien-2-yl]-9H-fluoren-9-ol (Example 3v) and Nα -(9-fluorenylmethoxycarbonyl)-L-threonine methyl ester following method A, using trifluoroacetic acid as catalyst in place of H2SO4 ;

Sources & evidence

ORD record
ord-e7c1faf98cd94b8bb137a01c16040631
Source dataset
uspto-grants-2000_12
Patent number
US06162824

Reaction notes

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