Sulfuric Acid → HCID 54290267, compound

HRID 1275779Notes

Reaction equation

HRID 1275779 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:13]=[CH:12][S:11][C:10]=2[C:14]2([OH:27])[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:20]3[C:15]2=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:5][CH:4]=1.C[O:29][C:30](=[O:53])[C@H:31]([C@@H:50]([CH3:52])O)[NH:32]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O.OS(O)(=O)=O>FC(F)(F)C(O)=O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:13]=[CH:12][S:11][C:10]=2[C:14]2([O:27][C@H:50]([CH3:52])[C@@H:31]([C:30]([OH:53])=[O:29])[NH2:32])[C:26]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[C:20]3[C:15]2=[CH:16][CH:17]=[CH:18][CH:19]=3)=[CH:7][CH:8]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 11164107HCID 11164107, compoundHCID 22117493HCID 22117493, compound

Product 1

HCID 54290267HCID 54290267, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidCatalyst

Procedure

from 9-[3-(4-methoxyphenyl)thien-2-yl]-9H-fluoren-9-ol (Example 3w) and Nα -(9-fluorenylmethoxycarbonyl)-L-threonine methyl ester following method A, using trifluoroacetic acid as catalyst in place of H2SO4 ;

Sources & evidence

ORD record
ord-11da043e7cd442b5b33cf2989dd86737
Source dataset
uspto-grants-2000_12
Patent number
US06162824

Reaction notes

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