Sulfuric Acid → HCID 9951009, compound

HRID 1275781Notes

Reaction equation

HRID 1275781 reaction equation
[C:1]1([C:7]2([OH:19])[C:15]3[S:16][CH:17]=[CH:18][C:14]=3[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]2=3)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[O:21][C:22](=[O:45])[C@H:23]([C@@H:42]([CH3:44])O)[NH:24]C(OCC1C2C=CC=CC=2C2C1=CC=CC=2)=O.OS(O)(=O)=O>FC(F)(F)C(O)=O>[C:1]1([C:7]2([O:19][C@H:42]([CH3:44])[C@@H:23]([C:22]([OH:45])=[O:21])[NH2:24])[C:15]3[S:16][CH:17]=[CH:18][C:14]=3[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]2=3)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 11164107HCID 11164107, compoundHCID 22117572HCID 22117572, compound

Product 1

HCID 9951009HCID 9951009, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidCatalyst

Procedure

from 8-phenyl-8H-indeno[2,1-b]thiophen-8-ol (Example 1pp) and Nα -(9-fluorenylmethoxycarbonyl)-L-threonine methyl ester following method A, using trifluoroacetic acid as catalyst in place of H2SO4 ;

Sources & evidence

ORD record
ord-37a7253edec84ee9aa88d8dd55eab17d
Source dataset
uspto-grants-2000_12
Patent number
US06162824

Reaction notes

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