反应详情

20 g (0.156 mol) of 1-aminocyclopentane-1-carboxamide and 28 g (0.19 mol) of trimethyl orthoformate are refluxed for 1 hour. The condenser is then changed to a "No hold up" condenser, and the temperature is elevated to 140° C. inner temperature. The residue is dissolved in 150 ml of acetone the pH is adjusted to 1-2 with concentrated hydrochloric acid and after cooling the resulting suspension the product is filtered of. 25 g of the title compound is obtained, yield 92.2%.

1. customis elevated to 140° C.
2. temperatureafter cooling the resulting suspension the product
3. filtrationis filtered of