HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 1-Methyl-beta-oxo-alpha-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | 1-Methyl-beta-oxo-alpha-ethoxycarbonyl-2-pyrrolepropionitrile | HCID 20285413 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 1-Methyl-beta-oxo-alpha-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile | HCID 9993968 | — |
Reaction Steps
The mixture of 5.7 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 3,6 g of p-aminophenol and 300 ml of xylene is refluxed for 2 hours and filtered hot. The filtrate is chilled, the crystals formed collected and recrystallized from methanol, to yield the 1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile melting at 182°-184°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04256759 |
| Source dataset | uspto-grants-1981_03 |
| ORD ID | ord-1fbb6d3ae0e0441cb4d8de881ca8e099 |
| Source note | uspto-grants-1981_03 |