反应详情

The mixture of 5.7 g of 1-methyl-β-oxo-α-ethoxycarbonyl-2-pyrrolpropionitrile, 3,6 g of p-aminophenol and 300 ml of xylene is refluxed for 2 hours and filtered hot. The filtrate is chilled, the crystals formed collected and recrystallized from methanol, to yield the 1-methyl-β-oxo-α-(p-hydroxyphenylcarbamoyl)-2-pyrrolpropionitrile melting at 182°-184°.

1. temperatureis refluxed for 2 hours
2. filtrationfiltered hot
3. temperatureThe filtrate is chilled
4. customthe crystals formed
5. customcollected
6. customrecrystallized from methanol