HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → HCID 131722227, Verbindung
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 4-Thiazoleacetic acid, 2-amino-, ethyl ester | HCID 104454 | — |
| Edukt | PyBroP | HCID 2733179 | — |
| Edukt | 2-[[5-{2,8-Dimethyl-5H-dibenzo[a,d]cyclohepten-5-yl}-3,4-dihydro-2-oxo-4-thioxo-1(2H)-pyrimidinyl]methyl]-4-thiazolecarboxylic acid | HCID 22117231 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | HCID 131722227 | HCID 131722227 | — |
Reaktionsschritte
The product from example 8(0.11 g) and 2-amino-4-thiazoleacetic acid ethyl ester (0.063 g) were dissolved in dry dimethylformamide (5 ml). Bromo-tris(pyrrolidino)-phosphonium hexafluorophosphate (0.11 g) and triethylamine (0.08 ml) were added and the mixture was stirred at room temperature for 24 hours. The reaction mixture was quenched with brine/HCl and extracted with ethyl acetate. The extract was washed with water, dried (MgSO4) and evaporated. The residue was purified by chromatography eluting with 10% ethyl acetate in dichloromethane and used directly in the next step.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US06162808 |
| Quelldatensatz | uspto-grants-2000_12 |
| ORD ID | ord-3b64e6a53f9e49199d86902ef1ac3d21 |
| Quellennotiz | uspto-grants-2000_12 |