反应详情

The product from example 8(0.11 g) and 2-amino-4-thiazoleacetic acid ethyl ester (0.063 g) were dissolved in dry dimethylformamide (5 ml). Bromo-tris(pyrrolidino)-phosphonium hexafluorophosphate (0.11 g) and triethylamine (0.08 ml) were added and the mixture was stirred at room temperature for 24 hours. The reaction mixture was quenched with brine/HCl and extracted with ethyl acetate. The extract was washed with water, dried (MgSO4) and evaporated. The residue was purified by chromatography eluting with 10% ethyl acetate in dichloromethane and used directly in the next step.

1. customThe reaction mixture was quenched with brine/HCl
2. extractionextracted with ethyl acetate
3. washThe extract was washed with water
4. dry with materialdried (MgSO4)
5. customevaporated
6. customThe residue was purified by chromatography
7. washeluting with 10% ethyl acetate in dichloromethane