Phosphorus tribromide → 1-(Bromomethyl)-2,3-dimethylbenzene

HRID 1275904Notes

Reaction equation

HRID 1275904 reaction equation
O[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[CH3:10].P(Br)(Br)[Br:12]>C1C=CC=CC=1.C1(C)C=CC=CC=1>[Br:12][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[C:4]=1[CH3:10]

Participants

5

Reactant 2

HCID 24614Phosphorus tribromideHCID 96208(2,3-Dimethylphenyl)methanol

Product 1

HCID 1136271-(Bromomethyl)-2,3-dimethylbenzene

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 1140TolueneSolvent

Procedure

A mixture of 1-hydroxymethyl-2,3-dimethylbenzene (ref) (5 g) and phosphorous tribromide (1.16 ml) in benzene (50 ml) was heated at reflux for 3 hours. The mixture was diluted with toluene, washed with water, dried (MgSO4) and evaporated. Yield 7 g.

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 3 hours
  3. washwashed with water
  4. dry with materialdried (MgSO4)
  5. customevaporated

Sources & evidence

ORD record
ord-f25708848ecf4d70a9b64b1ebba36797
Source dataset
uspto-grants-2000_12
Patent number
US06162808

Reaction notes

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