反应详情

n-Butyllithium (6.9 ml of a 2.5M soln in hexanes) was added dropwise to the product of example 21 step (i) (3.51 g) in tetrahydrofuran (60 ml) at -78° C. After 2 hours the product from step (i) (3.45 g) was added. After 1 hour the solution was left to warm to room temperature. The solution was quenched with water and extracted with ethyl acetate. The organic solution was dried (MgSO4) and evaporated under reduced pressure. Yield 1.83 g.

1. customThe solution was quenched with water
2. extractionextracted with ethyl acetate
3. dry with materialThe organic solution was dried (MgSO4)
4. customevaporated under reduced pressure