HCID 54554180, compound → HCID 22117269, compound

HRID 1275920Notes

Reaction equation

HRID 1275920 reaction equation
[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH:19]=[CH:20][CH3:21])[CH:14]=2)[CH:3]=1>C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([CH2:19][CH2:20][CH3:21])[CH:14]=2)[CH:3]=1

Participants

4

Reactant 1

HCID 54554180HCID 54554180, compound

Product 1

HCID 22117269HCID 22117269, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The subtitle compound was prepared from the product of step (iv) (15.4 g) by the method of example 21 step (iii). The crude reaction product was contaminated with 4-methyl-2-[2-[3-[1-propenyl]phenyl]ethyl]benzoic acid. The crude reaction product was dissolved in ethyl acetate (100 ml) and the solution was hydrogenated over 10% palladium on carbon (1 g) at 3 atmospheres pressure for 2 hours. The catalyst was removed by filtration and the filtrate was evaporated. Yield 12.8 g.

Workup

  1. customThe crude reaction product
  2. customThe crude reaction product
  3. customThe catalyst was removed by filtration
  4. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-9002dbbe7fa848f3b8718ac1543ac9f4
Source dataset
uspto-grants-2000_12
Patent number
US06162808

Reaction notes

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