Sodium Cyanide → 4-(Trifluoromethylsulphonyl)benzonitrile

Under an atmosphere of nitrogen, a mixture of 4 g of bis-triphenylphosphine-nickel dichloride, 3 g of triphenylphosphine and 100 ml of MEK was stirred at room temperature for 10 minutes. 1.2 g of activated zinc powder were then added, and the reaction mixture was stirred at 70° C. for 30 minutes. Following this, the mixture was allowed to cool to 25° C., and a solution of 92 g of 4-chloro-trifluoromethanesulphonylbenzene in 50 ml of MEK was added dropwise. The mixture was stirred for 10 minutes, 18.5 g of sodium cyanide were then added and the reaction mixture was stirred at from 65 to 70° C. for 20 h. The conversion after this period of time was greater than 98% (GC). After cooling to RT, the mixture was filtered, the solid filter residue was washed 2× with 30 ml of MEK each time and the combined organic phases were concentrated under reduced pressure. Fractionation under reduced pressure via a 30 cm Vigreux column and heated distillation bridge gave 76 g (85% of theory) of 4-trifluoromethanesulphonylbenzonitrile as a white solid (boiling point at 0.2 mbar: 115° C.). A formation of coupling products was not observed.

1. stirringthe reaction mixture was stirred at 70° C. for 30 minutes
2. temperatureto cool to 25° C.
3. stirringThe mixture was stirred for 10 minutes
4. stirringthe reaction mixture was stirred at from 65 to 70° C. for 20 h
5. waitThe conversion after this period of time was
6. temperatureAfter cooling to RT
7. filtrationthe mixture was filtered
8. filtrationthe solid filter residue
9. washwas washed 2× with 30 ml of MEK each time
10. concentrationthe combined organic phases were concentrated under reduced pressure
11. temperatureFractionation under reduced pressure via a 30 cm Vigreux column and heated
12. distillationdistillation bridge

ORD record

ord-59d5f242b0194011a10495418521bce0

Source dataset

uspto-grants-2000_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06162942