1,4-Dioxane hydrochloride → N-Propyl-N-propoxyamine hydrochloride

HRID 1275993Notes

Reaction equation

HRID 1275993 reaction equation
C([N:8]([CH2:13][CH2:14][CH3:15])[O:9][CH2:10][CH2:11][CH3:12])(OC(C)(C)C)=O.[ClH:16].O1CCOCC1>>[ClH:16].[CH2:13]([NH:8][O:9][CH2:10][CH2:11][CH3:12])[CH2:14][CH3:15]

Participants

3

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 22322626N-Boc-N-propyl-N-propoxyamine

Product 1

HCID 22322517N-Propyl-N-propoxyamine hydrochloride

Procedure

N-Boc-N-propyl-N-propoxyamine (5.8 g) was dissolved in 4N HCl/dioxane (10 mL) and stirred at room temperature for 7 hours. The solvent was removed in vacuo and the residue triturated with diethyl ether. The resulting yellow solid (2.1 g) was collected by filtration and washed with diethyl ether.

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residue triturated with diethyl ether
  3. filtrationThe resulting yellow solid (2.1 g) was collected by filtration
  4. washwashed with diethyl ether

Sources & evidence

ORD record
ord-27f15a45884d4ca9897fa94cdfaa408c
Source dataset
uspto-grants-2000_12
Patent number
US06162927

Reaction notes

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