HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → t-Butyl bicyclo[2,2,2]oct-5-ene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,3-Cyclohexadiene | HCID 11605 | — |
| Reactant | tert-Butyl acrylate | HCID 15458 | — |
| Product | t-Butyl bicyclo[2,2,2]oct-5-ene-2-carboxylate | HCID 18413667 | 48% |
Reaction Steps
Cyclohexadiene (80g) and 154 g of t-butyl acrylate were dissolved in 500 g of THF solvent. After reacting at 50° C. for 24 hours, the solvent was removed by rotary evaporator. The residue was distilled under reduced pressure to obtain 112 g of t-butyl bicyclo[2,2,2]oct -5-ene-2-carboxylate as a mixture of endo and exo (yield: 48%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06165672 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-1038331efefc459bae1e2cd21ec1f519 |
| Source note | uspto-grants-2000_12 |