HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → 2-Hydroxyethyl bicyclo[2,2,2]oct-5-ene-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 1,3-Cyclohexadiene | HCID 11605 | — |
| Reactant | 2-Hydroxyethyl acrylate | HCID 13165 | — |
| Product | 2-Hydroxyethyl bicyclo[2,2,2]oct-5-ene-2-carboxylate | HCID 18413666 | 51% |
Reaction Steps
Cyclohexadiene (80 g) and 140 g of 2-hydroxyethyl acrylate were dissolved in 500 g of THF solvent. After reacting at 50° C. for 24 hours, the solvent was removed by rotary evaporator. The residue was distilled under reduced pressure to obtain 100 g of 2-hydroxyethyl bicyclo[2,2,2]oct-5-ene-2- carboxylate as a mixture of endo and exo (yield: 45%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06165672 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-fc14b68eaa4a4e5d9c807ccda287c9ba |
| Source note | uspto-grants-2000_12 |