Ethyl orthoformate → HCID 22114878, compound

HRID 1276046Notes

Reaction equation

HRID 1276046 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[C:9]2[NH:19][NH2:20])=[CH:4][CH:3]=1.[CH:21](OCC)(OCC)OCC>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:16])[F:17])[N:10]3[CH:21]=[N:20][N:19]=[C:9]23)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31214Ethyl orthoformateHCID 22114874HCID 22114874, compound

Product 1

HCID 22114878HCID 22114878, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 3-(4-chlorophenyl)-3,4-dihydro-2-hydrazino-6-trifluoromethylpyrimidin-4-one (0.7 g), triethyl orthoformate (1.0 g) and acetic acid (10 ml) was heated for one hour at 120° C. The solvent was distilled off under reduced pressure and the residue was purified by a preparative thin-layer plate of silica gel (developing solvent: ethyl acetate/hexane=4/6) to give the compound of interest (0.45 g).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by a preparative thin-layer plate of silica gel (developing solvent: ethyl acetate/hexane=4/6)
  3. customto give the compound of interest (0.45 g)

Sources & evidence

ORD record
ord-e55403ab8837426d8f87425c92f8204c
Source dataset
uspto-grants-2000_12
Patent number
US06165942

Reaction notes

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