Ethyl orthoformate → HCID 22114878, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(4-chlorophenyl)-3,4-dihydro-2-hydrazino-6-trifluoromethylpyrimidin-4-one (0.7 g), triethyl orthoformate (1.0 g) and acetic acid (10 ml) was heated for one hour at 120° C. The solvent was distilled off under reduced pressure and the residue was purified by a preparative thin-layer plate of silica gel (developing solvent: ethyl acetate/hexane=4/6) to give the compound of interest (0.45 g).

Provenance & Evidence