Ammonia → HCID 22114890, compound

HRID 1276047Notes

Reaction equation

HRID 1276047 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=[C:9]2S(C)(=O)=O)=[CH:4][C:3]=1[C:23]([O:25][CH2:26][CH3:27])=[O:24].[NH3:28]>C1COCC1>[NH2:28][C:9]1[N:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[C:3]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH:4]=2)[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 22114879HCID 22114879, compound

Product 1

HCID 22114890HCID 22114890, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a mixture of 3-(4-chloro-3-ethoxycarbonylphenyl)-3,4-dihydro-2-methanesulfonyl-6-trifluoromethylpyrimidin-4-one (1.0 g) and dry THF (50 ml) was blown an ammonia gas until the starting material was not found when detected with TLC. The mixture was dried on anhydrous magnesium sulfate and then the solvent was distilled off under reduced pressure. The thus obtained white solid (0.7 g) was used in the next reaction without purifying it.

Workup

  1. dry with materialThe mixture was dried on anhydrous magnesium sulfate
  2. distillationthe solvent was distilled off under reduced pressure
  3. customThe thus obtained white solid (0.7 g) was used in the next reaction
  4. customwithout purifying it

Sources & evidence

ORD record
ord-9b6d2e4866b2415283b1b52968ffd049
Source dataset
uspto-grants-2000_12
Patent number
US06165942

Reaction notes

Loading…