Chlorosuccinimide → HCID 22114892, compound

HRID 1276061Notes

Reaction equation

HRID 1276061 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]3[CH:19]=[CH:20][N:21]=[C:9]23)=[C:4]([F:22])[CH:3]=1.[Cl:23]N1C(=O)CCC1=O>C(#N)C>[Cl:23][C:20]1[N:21]=[C:9]2[N:8]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=3[F:22])[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:17])([F:18])[F:16])[N:10]2[CH:19]=1

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 22114880HCID 22114880, compound

Product 1

HCID 22114892HCID 22114892, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A mixture of 8-(4-chloro-2-fluorophenyl)-7,8-dihydro-5-trifluoromethylimidazo[1,2-a]pyrimidin-7-one (1.0 g), N-chlorosuccinimide (0.4 g) and acetonitrile (30 ml) was heated to reflux for 3 hours. The solvent was distilled off under reduced pressure and the residue was purified by a preparative thin-layer plate of silica gel (developing solvent: ethyl acetate/hexane=2/8) to give the compound of interest (0.3 g).

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 3 hours
  3. distillationThe solvent was distilled off under reduced pressure
  4. customthe residue was purified by a preparative thin-layer plate of silica gel (developing solvent: ethyl acetate/hexane=2/8)
  5. customto give the compound of interest (0.3 g)

Sources & evidence

ORD record
ord-c27b5829a4e64cbdac42a8e27106c51b
Source dataset
uspto-grants-2000_12
Patent number
US06165942

Reaction notes

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