HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Bromide → HCID 136134492, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Bromide | HCID 260 | — |
| Reactant | 4-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]phenyl methyl ether | HCID 16412784 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 136134492 | HCID 136134492 | — |
Reaction Steps
A suspension of 10.0 g (34.8 mmol) of 3-chloro-2-(4-methoxyphenyl)-5-trifluoromethylpyridine in 50 ml of 47% strength hydrobromic acid was heated at reflux temperatures for two hours. After cooling, the reaction mixture was diluted with 200 ml of water. After cooling for a few hours, the resulting crystals were separated off, washed with water and dried under reduced pressure. Yield: 8.0 g (84%) of colorless crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06165941 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-b2c4a77541344300927b563253cb31d7 |
| Source note | uspto-grants-2000_12 |