Hydrogen Bromide → HCID 136134492, compound

HRID 1276073Notes

Reaction equation

HRID 1276073 reaction equation
[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([O:18]C)=[CH:14][CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.Br>O>[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:9])[F:10])[CH:7]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 16412784HCID 16412784, compound

Product 1

HCID 136134492HCID 136134492, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A suspension of 10.0 g (34.8 mmol) of 3-chloro-2-(4-methoxyphenyl)-5-trifluoromethylpyridine in 50 ml of 47% strength hydrobromic acid was heated at reflux temperatures for two hours. After cooling, the reaction mixture was diluted with 200 ml of water. After cooling for a few hours, the resulting crystals were separated off, washed with water and dried under reduced pressure. Yield: 8.0 g (84%) of colorless crystals.

Workup

  1. temperaturewas heated
  2. temperatureat reflux temperatures for two hours
  3. temperatureAfter cooling
  4. temperatureAfter cooling for a few hours
  5. customthe resulting crystals were separated off
  6. washwashed with water
  7. customdried under reduced pressure

Sources & evidence

ORD record
ord-b2c4a77541344300927b563253cb31d7
Source dataset
uspto-grants-2000_12
Patent number
US06165941

Reaction notes

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