HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetonitrile → 5-(3-Chloro-5-trifluoromethylpyridin-2-yl)-3-cyanomethyl-1-(1-methylethyl)benzimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetonitrile | HCID 11534 | — |
| Reactant | 5-(3-Chloro-5-trifluoromethylpyridin-2-yl)-3-methyl-1-(1-methylethyl)benzimidazol-2-one | HCID 22114840 | — |
| Reactant | 5-(3-Chloro-5-trifluoromethylpyridin-2yl)-1-(1-methylethyl)benzimidazol-2-one | HCID 22114855 | — |
| Product | 5-(3-Chloro-5-trifluoromethylpyridin-2-yl)-3-cyanomethyl-1-(1-methylethyl)benzimidazol-2-one | HCID 22114858 | 50% |
Reaction Steps
In a similar manner to the preparation of 5-(3-chloro-5-trifluoromethylpyridin-2-yl)-3-methyl-1-(1-methylethyl)benzimidazol-2-one described above, 2.5 g of 5-(3-chloro-5-trifluoromethylpyridin-2-yl)-1-(1-methylethyl)benzimidazol-2-one and 0.9 g of bromoacetonitrile gave, after chromatography on silica gel, 1.4 g of colorless crystals. Yield: 50%; m.p.: 158-159° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06165941 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-29d2c8a1456e4b3abfb488ed778d49d8 |
| Source note | uspto-grants-2000_12 |