HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → 5-(3-Chloro-5-trifluoromethylpyridin-2yl)-3-ethoxycarbonylmethyl-1-(1-methylethyl)benzimidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 5-(3-Chloro-5-trifluoromethylpyridin-2-yl)-3-methyl-1-(1-methylethyl)benzimidazol-2-one | HCID 22114840 | — |
| Reactant | 5-(3-Chloro-5-trifluoromethylpyridin-2yl)-1-(1-methylethyl)benzimidazol-2-one | HCID 22114855 | — |
| Product | 5-(3-Chloro-5-trifluoromethylpyridin-2yl)-3-ethoxycarbonylmethyl-1-(1-methylethyl)benzimidazol-2-one | HCID 22114867 | 68% |
Reaction Steps
In a similar manner to the preparation of 5-(3-chloro-5-trifluoromethylpyridin-2yl)-3-methyl-1-(1-methylethyl)benzimidazol-2-one described above, 2.5 g of 5-(3-chloro-5-trifluoromethyl-pyridin-2yl)-1-(1-methylethyl)benzimidazol-2 -one and 1.23 g of ethyl bromoacetate gave 2.1 g (68%) of colorless crystals. Yield: 68%, m.p.L 125-127° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06165941 |
| Source dataset | uspto-grants-2000_12 |
| ORD ID | ord-50105b9f88e642099377114110bbe33d |
| Source note | uspto-grants-2000_12 |