反应详情

温度

23 °C

A solution of 50.0 g of 3-chloro-2-(4-fluoro-3-nitrophenyl)-5-trifluoromethylpyridine in 200 ml of tetrahydrofuran was treated with 200 g of a 25% strength by weight aqueous ammonia solution. After stirring at 23° C. for three days, the tetrahydrofuran was removed by distillation, whereupon the product crystallized. The crystals were separated off, washed with water and dried in a vacuum drying oven. Yield: 48.7 g (98%) of colorless crystals; m.p.: 126-127° C.

1. customthe tetrahydrofuran was removed by distillation, whereupon the product
2. customcrystallized
3. customThe crystals were separated off
4. washwashed with water
5. customdried in a vacuum
6. customdrying oven