Hydrochloric Acid → HCID 67519695, compound

HRID 12761Notes

Reaction equation

HRID 12761 reaction equation
[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][C@H:20]3[C@:18]([C:22]4[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=4)([CH2:19]3)[CH2:17]2)[CH:12]=1.[ClH:34]>O1CCOCC1>[ClH:34].[CH3:1][C:2]1[CH:6]=[CH:5][S:4][C:3]=1[C:7]1[C:8](=[O:33])[NH:9][C:10](=[O:32])[N:11]([CH2:13][CH2:14][CH2:15][N:16]2[CH2:21][C@H:20]3[C@:18]([C:22]4[CH:23]=[CH:24][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:26][CH:27]=4)([CH2:19]3)[CH2:17]2)[CH:12]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 247591145-(3-methyl-2-thienyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 67519695HCID 67519695, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

5-(3-methyl-2-thienyl)-1-(3-{(1S,5R)-1-[4-(trifluoromethyl)phenyl]-3-azabicyclo[3.1.0]hex-3-yl}propyl)-2,4(1H,3H)-pyrimidinedione was treated with a solution of 4N HCl in dioxane (200 μl) to give the title compound as a white solid.

Sources & evidence

ORD record
ord-2bc75666da7441768afee2de1270b31a
Source dataset
uspto-grants-2010_06
Patent number
US07727988B2

Reaction notes

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