反应详情

温度

110 °C

At 50° C., 74.8 g (0.63 mol) of thionyl chloride in 50 ml of dry toluene were added dropwise to a solution of 139.0 g of 2-chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoic acid, 1 ml of dimethylformamide and 1 l of dry toluene. The mixture was heated to 110° C. for 6 hours, after which the solvent was distilled off. 2-Chloro-3-(4,5-dihydroisoxazol-3-yl)-4-methylsulfonylbenzoyl chloride was obtained in quantitative yield.

1. distillationafter which the solvent was distilled off