Lithium Hydroxide → (2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid

HRID 1276172Notes

Reaction equation

HRID 1276172 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([O:18]CC3C=CC=CC=3)=[O:17])=[N:7][C:6]=2[CH:26]=1.[OH-].[Li+]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([N:10]3[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]3[C:16]([OH:18])=[O:17])=[N:7][C:6]=2[CH:26]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 53932308benzyl(2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate

Product 1

HCID 53730159(2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid

Procedure

The title compound was prepared by a similar method to Preparation 3 from benzyl (2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylate [see Preparation 28] and 1N aqueous lithium hydroxide solution to afford (2S)-1-(5-chloro-1,3-benzoxazol-2-yl)-2-piperidinecarboxylic acid as an oil.

Sources & evidence

ORD record
ord-8709320d1e2a41ca8590d519688aee2c
Source dataset
uspto-grants-2000_12
Patent number
US06166011

Reaction notes

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