反应详情

To a mixture of 3-methylthiopropylamine (30.0 g, 0.285 mol) and sodium bicarbonate (12.0 g, 0.142 mol) in 250 ml of ethanol was added dropwise bromo-t-butyl acetate (27.8 g, 0.142 mol). After 5 hours the ethanol was removed on a rotary evaporator and the residue partitioned between water and chloroform. The chloroform layer was dried, filtered and concentrated to give 36.4 g of crude N-(3-methylthiopropyl)glycine t-butyl ester as an oil.

1. customAfter 5 hours the ethanol was removed on a rotary evaporator
2. customthe residue partitioned between water and chloroform
3. dry with materialThe chloroform layer was dried
4. filtrationfiltered
5. concentrationconcentrated