HCID 22115827, compound → HCID 22115821, compound

HRID 1276199Notes

Reaction equation

HRID 1276199 reaction equation
[ClH:1].[CH3:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([N+:13]([O-])=O)=[CH:8][CH:9]=2)[CH2:4]1>CO.[Pd]>[ClH:1].[CH3:2][N:3]1[CH2:12][CH2:11][C:10]2[C:5](=[CH:6][C:7]([NH2:13])=[CH:8][CH:9]=2)[CH2:4]1

Participants

4

Reactant 1

HCID 22115827HCID 22115827, compound

Product 1

HCID 22115821HCID 22115821, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 23938PalladiumSolvent

Procedure

2-Methyl-7-nitro-1,2,3,4-tetrahydroisoquinoline hydrochloride was dissolved in methanol and hydrogenated at 50 psi in the presence of a catalytic quantity of 10% Pd-C. After 1 h the mixture was filtered through glass and evaporated to provide 2-methyl-1,2,3,4-tetrahydroisoquinolin-7-ylamine hydrochloride, m.p. 137-138° C.

Workup

  1. filtrationAfter 1 h the mixture was filtered through glass
  2. customevaporated

Sources & evidence

ORD record
ord-8844821156a943dd9cb750a46fbbd4c6
Source dataset
uspto-grants-2000_12
Patent number
US06166030

Reaction notes

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