Thiophene → 5-Chloro-1-(2-thienyl)-1-pentanone

HRID 1276282Notes

Reaction equation

HRID 1276282 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[S:5]1[CH:9]=[CH:8][CH:7]=[CH:6]1.[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15](Cl)=[O:16]>>[Cl:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]([C:6]1[S:5][CH:9]=[CH:8][CH:7]=1)=[O:16]

Participants

4

Reactant 3

HCID 8030ThiopheneHCID 740895-Chlorovaleryl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 49129955-Chloro-1-(2-thienyl)-1-pentanone

Procedure

16 g (0.120 mol) of aluminium chloride are introduced portionwise over 15 min into a solution, maintained at about +5°, of 20.2 g (0.240 mol) of thiophene and 15.5 g (0.100 mol) of 5-chlorovaleryl chloride and the mixture is stirred for 5 h at room temperature. After removal of the supernatant by means of separating the phases by settling, the reaction medium is taken up in 120 ml of 3N hydrochloric acid solution and extracted with chloroform.

Workup

  1. customAfter removal of the supernatant by means
  2. customof separating the phases
  3. extractionextracted with chloroform

Sources & evidence

ORD record
ord-5f9acfc393da4ac290bc9515b1fbd107
Source dataset
uspto-grants-2000_12
Patent number
US06166035

Reaction notes

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