反应详情

A stirred suspension of 4-(6-amino-2-methylpyridin-3-yl)benzoic acid hydrochloride (D6, 1.9 g, 8.3 mmole) in methanol (120 ml) was treated with conc. HCl acid (1 ml) and heated under reflux for 2 h. The solution was concentrated in vacuo, the residue treated with excess 10% Na2CO3 solution and extracted with ethyl acetate. The extract was dried (Na2SO4) and concentrated in vacuo to afford the title compound as a pale yellow solid (1.4 g, 70%).

1. temperatureheated
2. temperatureunder reflux for 2 h
3. concentrationThe solution was concentrated in vacuo
4. additionthe residue treated with excess 10% Na2CO3 solution
5. extractionextracted with ethyl acetate
6. dry with materialThe extract was dried (Na2SO4)
7. concentrationconcentrated in vacuo