反应详情

3,4-Dichlorobenzoylacetonitrile (3.0 g) was dissolved in ethanol (15 ml) to which was subsequently added hydrazine monohydrate (0.67 ml) while cooling with ice. The mixture was heatedunder reflux for 5 hours and allowed to cool. Then, the solvent was distilled away under a reduced pressure. The resulting residue was recrystallized from ethyl acetate-hexane to obtain the title compound (1.72 g) as colorless crystals (melting point: 169-170° C.).

1. temperaturewhile cooling with ice
2. temperaturereflux for 5 hours
3. temperatureto cool
4. distillationThen, the solvent was distilled away under a reduced pressure
5. customThe resulting residue was recrystallized from ethyl acetate-hexane